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Asperosaponin VI Promotes Progesterone Receptor Expression in Decidual Cells via the Notch Signaling Pathway

Asperosaponin VI Promotes Progesterone Receptor Expression in Decidual Cells via the Notch Signaling Pathway

Jie Gao, Chun Zhou, Yadi Li, Feixia Gao, Haiwang Wu, Lilin Yang, Weiyu Qiu, Lin Zhu, Xin Du, Weixian Lin, Dandan Huang, Haibin Liu, Chun Liang, Songping Luo

Fitoterapia. 2016 Sep;113:58-63.

PMID: 27370099

Abstract:

Recurrent spontaneous abortion (RSA) is a common clinical condition, but its reasons remain unknown in 37-79% of the affected women. The steroid hormone progesterone (P4) is an integral mediator of early pregnancy events, exerting its effects via the progesterone receptor (PR). Dipsaci Radix (DR) has long been used for treating gynecological diseases in Chinese medicine, while its molecular mechanisms and active ingredients are still unclear. We report here the progesterone-like effects of the alcohol extraction and Asperosaponin VI from DR in primary decidual cells and HeLa cell line. We first determined the safe concentration of Asperosaponin VI in the cells with MTT assay and then found by using dual luciferase reporter and Western blotting that Asperosaponin VI significantly increased PR expression. Moreover, we explored the mechanisms of action of the DR extracts and Asperosaponin VI, and the results showed that they could activate Notch signaling, suggesting that they may function by promoting decidualization.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP39524088-A	Asperosaponin VI		39524-08-8	Price

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