Home
Resources
Publications
Assembly of the Mycobacterial Cell Wall

Assembly of the Mycobacterial Cell Wall

Monika Jankute, Jonathan A G Cox, James Harrison, Gurdyal S Besra

Annu Rev Microbiol. 2015;69:405-23.

PMID: 26488279

Abstract:

Mycobacterium tuberculosis remains one of the most successful bacterial pathogens, claiming over 1.3 million lives worldwide in 2013. The emergence of multidrug-resistant and extensively drug-resistant isolates has prompted the need for new drugs and drug targets. M. tuberculosis possesses an unusual cell wall dominated by lipids and carbohydrates that provides a permeability barrier against hydrophilic drugs and is crucial for its survival and virulence. This large macromolecular structure, termed the mycolyl-arabinogalactan-peptidoglycan complex, and the phosphatidyl-myo-inositol-based lipoglycans are key features of the mycobacterial cell wall. Assembly of these cell wall components is an attractive target for the development of chemotherapeutics against tuberculosis. Herein, we focus on recent biochemical and molecular insights into these complex molecules of M. tuberculosis cell wall.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9036662	(+)-Arabinogalactan		9036-66-2	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: