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Assessment of Elimination Profile of Albendazole Residues in Fish

Assessment of Elimination Profile of Albendazole Residues in Fish

Zenaís Busatto, Welliton Gonçalves de França, José Eurico Possebon Cyrino, Jonas Augusto Rizzato Paschoal

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018 Jan;35(1):77-85.

PMID: 29095112

Abstract:

Few drugs are specifically regulated for aquaculture. Thus this study considered albendazole (ABZ) as a potential drug for use in fish, which, however, is not yet regulated for this application. ABZ is a broad-spectrum anthelmintic approved for farmed ruminants and recently considered for treatment of fish parasites. It is the subject of careful monitoring because of potential residues in animal products. This study evaluated the depletion of ABZ and its main known metabolites: albendazole sulfoxide - ABZSO, albendazole sulfone - ABZSO2 and albendazole amino sulfone - ABZ-2-NH2SO2, in the fillets of the Neotropical Characin pacu, Piaractus mesopotamicus, which were fed diets containing 10 mg ABZ kg-1 body weight in a single dose. Fish were euthanised at 8, 12, 24, 48, 72, 96 and 120 hours after medication and the depletion profiles of ABZ, each metabolite and the sum of all marker residues were assessed and evaluated taking into account methodological variations regarding determination of the maximum residue limits adopted by different international regulating agencies for estimation of the withdrawal period (WP). The estimated WPs ranged from 2 to 7 days.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
CS35507	Residue - WP			Price

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