Home
Resources
Publications
Assessment of Embryotoxicity of Compounds in Cosmetics by the Embryonic Stem Cell Test

Assessment of Embryotoxicity of Compounds in Cosmetics by the Embryonic Stem Cell Test

Rui Chen, Jing Chen, Shujun Cheng, Jie Qin, Weiqiang Li, Lirong Zhang, Hong Jiao, Xinbing Yu, Xiuming Zhang, Bruce T Lahn, Andy Peng Xiang

Toxicol Mech Methods. 2010 Mar;20(3):112-8.

PMID: 20100057

Abstract:

The new EU legislations for cosmetics (Seventh Amendment) have laid down deadlines for the replacement of animal tests in cosmetics. This policy stimulates the acceptance of in vitro approaches to test embryotoxic potentials of compounds in cosmetics products. The embryonic stem cell test (EST) designed by The European Centre for the Validation of Alternative Methods (ECVAM) is currently the most promising in vitro assay to predict the embryotoxic potential of compounds. In this study, six selected compounds (hydroquinone, eugenol, dibutyl phthalate, antimony (III) oxide, neodymium (III) nitrate hydrate, melamine) formerly involved in cosmetic products were selected to test their embryotoxic potentials by the EST. 5-Fluorouracil and penicillin G were separately set as positive and negative control. The embryotoxic potential was determined by the prediction model (PM), which was calculated from three endpoints, the IC(50) 3T3, IC(50) ES, and ID(50). Hydroquinone, eugenol, and antimony (III) oxide indicated with strong embryotoxicity, while dibutyl phthalate, neodymium (III) nitrate hydrate, and melamine exhibited a weak embryotoxicity. These results may provide a valuable attempt to expand the application of EST to the cosmetics field.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP13746968	Neodymium(III) nitrate hydrate		13746-96-8	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: