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Assessment of Human 4-hydroxynonenal, 8-isoprostane Concentrations and Glutathione Reductase Activity After Synbiotics Administration

Assessment of Human 4-hydroxynonenal, 8-isoprostane Concentrations and Glutathione Reductase Activity After Synbiotics Administration

Paulina Kleniewska, Rafał Pawliczak

Adv Med Sci. 2018 Sep;63(2):301-305.

PMID: 29859494

Abstract:

Purpose:
Probiotics and prebiotics have become an object of intense research, to identify methods of mitigating oxidative stress. Over the past few years, the number of in vitro and in vivo studies, related to antioxidant properties of probiotics/prebiotics has significantly increased. The aim of the present study was to assess whether probiotic in combination with prebiotic influences the level of human 4-hydroxynonenal, 8-isoprostane and glutathione reductase activity.
Material/methods:
Experiments were carried out on healthy volunteers (male and female). All oxidative stress markers were measured in blood plasma pre- and post-administration of synbiotic.
Results:
The administration of synbiotic resulted in a significant decrease in 4-hydroxynonenal in the female-synbiotic group (p < 0.05), 8-isoprostanes in the female-synbiotic group and male-synbiotic group (p < 0.05) and non-significant increase in the activity of glutathione reductase (p > 0.05) vs. control.
Conclusions:
The present results show that supplementation of synbiotics contributed to the decrease in oxidative stress parameters in the female patients.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9001483	Glutathione Reductase human		9001-48-3	Price

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