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Association Between Caffeine Consumption and Depression in NHANES 2009-2010

Association Between Caffeine Consumption and Depression in NHANES 2009-2010

Janice M Pogoda, Galilea Patricio, Archana J McEligot

Calif J Health Promot. 2018;16(1):16-23.

PMID: 30853870

Abstract:

Background and purpose:
Caffeine is ubiquitous in foods, supplements, and medications and has been hypothesized to be associated with several health-related outcomes, including mental health disorders such as anxiety. We explored a possible relationship between caffeine consumption and depression using data from the National Health and Nutrition Examination Survey (NHANES).
Methods:
Data from 1,342 adult NHANES participants were included. Statistical software for complex survey sample designs was used to perform two multivariable logistic regressions with a binary indicator of depression as the dependent variable: one using dietary caffeine consumption and one using the caffeine metabolite AAMU as the independent variable. Both analyses were adjusted for gender, race/ethnicity, smoking status, and use of anti-depressants.
Results:
We observed a descriptive, albeit non-significant (p = 0.12), pattern of increasing odds of depression with increasing levels of the AAMU caffeine metabolite.
Conclusion:
Our finding of a possible association between caffeine metabolite level and depression is compelling because it is independent of self-reported caffeine consumption. Prospective studies are warranted to further explore the temporal relationship.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP19893788	AAMU		19893-78-8	Price

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