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Association of an Albumin Antigen With Phosphatidylcholine Liposomes Alters the Nature of Immunoglobulins Produced During the Immune Response Against the Antigen

Association of an Albumin Antigen With Phosphatidylcholine Liposomes Alters the Nature of Immunoglobulins Produced During the Immune Response Against the Antigen

N Van Rooijen, R Van Nieuwmegen

Biochim Biophys Acta. 1983 Feb 22;755(3):434-8.

PMID: 6824738

Abstract:

Human serum albumin has been injected intravenously in rabbits either free in solution or associated with liposomes. Blood samples were obtained from the rabbits at various time intervals after injection, and two different antibody determinations were performed in each sample. Whereas a haemagglutination technique was applied for determination of predominantly IgM anti-human serum albumin antibodies, a second technique, using antigen-coated Sepharose beads and horseradish peroxidase-conjugated anti-rabbit IgG, was used to detect the IgG anti-human serum albumin antibodies. Liposomes appeared to enhance strongly the IgM response against human serum albumin. No such marked differences were found, however, between the IgG responses against liposome-associated or free human serum albumin. The conclusion is drawn that the immunoadjuvant effect of liposomes during the primary immune response against an albumin antigen is mainly due to an enhanced IgM antibody production.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42417500	Anti-phospho-AKT1/3 (pTyr437/434) antibody produced in rabbit			Price

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