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Asymmetric Reduction of Acetophenone Into R-(+)-1-phenylethanol by Endophytic Fungus Neofusicoccum Parvum BYEF07 Isolated From Illicium Verum

Asymmetric Reduction of Acetophenone Into R-(+)-1-phenylethanol by Endophytic Fungus Neofusicoccum Parvum BYEF07 Isolated From Illicium Verum

Haiyun Li, Ziyuan Li, Guihua Ruan, Yankui Yu, Xiongmin Liu

Biochem Biophys Res Commun. 2016 May 13;473(4):874-878.

PMID: 27038548

Abstract:

Seventy-nine strains of endophytic fungi isolated from the healthy leaves, twigs and fruits of Illicium verum were screened for the asymmetric reduction activities to acetophenone. Strain BYEF07, which showed relatively high reduction activities, has been classified as Neofusicoccum parvum, and the main product was confirmed to be (R)-(+)-1-phenylethanol by GC-MS and chiral HPLC methods. The bio-reduction conditions of acetophenone by cells of N. parvum BYEF07 were investigated in detail. Under the conditions of 1.8 g/L of acetophenone, 100 g/L of microorganism cells and 10 g/L of glucose in 40 mL Na2HPO4 KH2PO4 buffer solution at pH7.5, 30 °C and 150 rpm, after 48 h reaction, the production yield of 1-phenylethanol and enantiomeric excess value of (R)-(+)-1-phenylethanol were 78% and 96%, respectively.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1517697	(R)-(+)-1-Phenylethanol		1517-69-7	Price

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