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Asymmetric Synthesis of Bryostatin 2

David A Evans, Percy H Carter, Erick M Carreira, Joëlle A Prunet, André B Charette, Mark Lautens

Angew Chem Int Ed Engl. 1998 Sep 18;37(17):2354-2359.

PMID: 29710955

Abstract:

The potent bryostatin antitumor agents are currently in phase II clinical trials for the treatment of a variety of forms of cancer. Aldol reactions and directed reductions are among the essential steps for the formation of fragments A-C in the total synthesis of the title compound. Coupling of these fragments by sulfone-based olefination and alkylation reactions was followed by macrocyclization and introduction of the enoate moieties on rings B and C.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP87745286 Bryostatin 2 Bryostatin 2 87745-28-6 Price
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