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ATN-161 Reduces Virus Proliferation in PHEV-infected Mice by Inhibiting the Integrin α5β1-FAK Signaling Pathway

ATN-161 Reduces Virus Proliferation in PHEV-infected Mice by Inhibiting the Integrin α5β1-FAK Signaling Pathway

Xiaoling Lv, Zi Li, Jiyu Guan, Jing Zhang, Baofeng Xu, Wenqi He, Yungang Lan, Kui Zhao, Huijun Lu, Deguang Song, Feng Gao

Vet Microbiol. 2019 Jun;233:147-153.

PMID: 31176401

Abstract:

Porcine hemagglutinating encephalomyelitis virus (PHEV) is a typical neurotropic virus that can cause obvious nerve damage. Integrin α5β1 is a transmembrane macromolecular that closely related to neurological function. We recently demonstrated that integrin α5β1 plays a critical role in PHEV invasion in vitro. To determine the function and mechanism of integrin α5β1 in virus proliferation in vivo, we established a mouse model of PHEV infection. Integrin α5β1-FAK signaling pathway was activated in PHEV-infected mice by qPCR, Western blotting, and GST pull-down assays. Viral proliferation and integrin α5β1-FAK signaling pathway were significantly inhibited after intravenous injection of ATN-161, an integrin α5β1 inhibitor. Through a histological analysis, we found that ATN-161-treated mice only showed pathological changes in neuronal cytoplasmic swelling at 5 day post-infection. In summary, our results provide the first evidence that ATN-161 inhibits the proliferation of PHEV in mice and explores its underlying mechanisms of action.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP262438437	ATN-161		262438-43-7	Price

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