Home
Resources
Publications
Atovaquone and Proguanil Hydrochloride for Prophylaxis of Malaria

Atovaquone and Proguanil Hydrochloride for Prophylaxis of Malaria

G D Shanks, P G Kremsner, T Y Sukwa, J D van der Berg, T A Shapiro, T R Scott, J D Chulay, Malarone Clinical Trials Study Group

J Travel Med. 1999 May;6 Suppl 1:S21-7.

PMID: 23573549

Abstract:

Background:
The spread of drug-resistant malaria and appreciation of side effects associated with existing antimalarial drugs emphasize the need for new drugs to prevent malaria. The combination of atovaquone and proguanil hydrochloride was previously shown to be safe and highly effective for treatment of malaria, including multi-drug-resistant Plasmodium falciparum.
Methods:
We reviewed results of clinical trials that evaluated either a fixed-dose combination of atovaquone and proguanil hydrochloride for malaria prophylaxis or atovaquone alone for causal prophylactic activity against P. falciparum.
Results:
In three placebo-controlled trials, 331 subjects received 250 mg atovaquone and 100 mg proguanil hydrochloride (or an equivalent dose based on body weight in children) once daily for 10 to 12 weeks. The overall efficacy for preventing parasitemia was 98%. Among 175 nonimmune volunteers taking the same dose of atovaquone/proguanil once daily for 10 weeks while temporarily residing in a malaria-endemic area, malaria developed in one patient who was noncompliant with therapy. Results of volunteer challenge studies indicate that both atovaquone and proguanil have causal prophylactic activity directed against the liver stages of P. falciparum. Adverse events occurred with similar or lower frequencies in subjects treated with atovaquone/proguanil compared to placebo. Less than 1% of patients discontinued from these studies due to a treatment-related adverse event.
Conclusion:
A fixed-dose combination of atovaquone and proguanil hydrocloride is a promising new alternative for malaria prophylaxis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP637321-A	Proguanil hydrochloride		637-32-1	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: