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Autobiographical Memory: A Candidate Latent Vulnerability Mechanism for Psychiatric Disorder Following Childhood Maltreatment

Autobiographical Memory: A Candidate Latent Vulnerability Mechanism for Psychiatric Disorder Following Childhood Maltreatment

Eamon J McCrory, Vanessa B Puetz, Eleanor A Maguire, Andrea Mechelli, Amy Palmer, Mattia I Gerin, Philip A Kelly, Iakovina Koutoufa, Essi Viding

Br J Psychiatry. 2017 Oct;211(4):216-222.

PMID: 28882830

Abstract:

BackgroundAltered autobiographical memory (ABM) functioning has been implicated in the pathogenesis of depression and post-traumatic stress disorder and may represent one mechanism by which childhood maltreatment elevates psychiatric risk.AimsTo investigate the impact of childhood maltreatment on ABM functioning.MethodThirty-four children with documented maltreatment and 33 matched controls recalled specific ABMs in response to emotionally valenced cue words during functional magnetic resonance imaging.ResultsChildren with maltreatment experience showed reduced hippocampal and increased middle temporal and parahippocampal activation during positive ABM recall compared with peers. During negative ABM recall they exhibited increased amygdala activation, and greater amygdala connectivity with the salience network.ConclusionsChildhood maltreatment is associated with altered ABM functioning, specifically reduced activation in areas encoding specification of positive memories, and greater activation of the salience network for negative memories. This pattern may confer latent vulnerability to future depression and post-traumatic stress disorder.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1125453088	Ogerin negative control		1125453-08-8	Price

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