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Autoradiography of [3H]U-69593 Binding Sites in Rat Brain: Evidence for Kappa Opioid Receptor Subtypes

Autoradiography of [3H]U-69593 Binding Sites in Rat Brain: Evidence for Kappa Opioid Receptor Subtypes

B Nock, A Rajpara, L H O'Connor, T J Cicero

Eur J Pharmacol. 1988 Sep 1;154(1):27-34.

PMID: 2846324

Abstract:

In vitro quantitative autoradiography was used to determine the distribution of [3H]U-69593 binding sites in rat brain. The highest density of binding was found in areas of the tel- and diencephalon while certain areas of the mes- and metencephalon were moderately labeled. The distribution of [3H]U-69593 binding sites corresponds closely (but not precisely) to the distribution of sites labeled by [3H]EKC and [3H]bremazocine at room temperature but differs substantially from the distribution of sites labeled by [3H]EKC at 4 degrees C (as described by others). These anatomical findings support previous biochemical evidence indicating that [3H]U-69593 selectively labels a kappa opioid receptor subtype with characteristics that differ from the kappa receptors labeled by [3H]EKC at 4 degrees C.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP96744751	U-69593		96744-75-1	Price

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