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Availability of Amino Acids Supplied Intravenously in Healthy Man as Synthetic Dipeptides: Kinetic Evaluation of L-alanyl-L-glutamine and glycyl-L-tyrosine

Availability of Amino Acids Supplied Intravenously in Healthy Man as Synthetic Dipeptides: Kinetic Evaluation of L-alanyl-L-glutamine and glycyl-L-tyrosine

S Albers, J Wernerman, P Stehle, E Vinnars, P Fürst

Clin Sci (Lond). 1988 Nov;75(5):463-8.

PMID: 3254762

Abstract:

1. For the first time utilization of intravenously administered L-alanyl-L-glutamine and glycyl-L-tyrosine was investigated by means of their kinetic behaviour after bolus injection in 10 and 11 apparently healthy male subjects (age 26.6 +/- 5.7 years), respectively. 2. The injection of the synthetic dipeptides was not accompanied by any side effects or complaints. 3. The synthetic dipeptides L-alanyl-L-glutamine and glycyl-L-tyrosine were rapidly cleared from plasma. By applying a monoexponential model the elimination half-lives were found to have very similar values (3.8 +/- 0.5 and 3.4 +/- 0.3 min) whether alanine or glycine was occupying the N-terminal position. The estimated volume of distribution was approximately that of the extracellular space. 4. Peptide disappearance was accompanied by a prompt equimolar increase in the concentrations of the constituent amino acids alanine and glutamine as well as glycine and tyrosine. 5. The study provides firm evidence that L-alanyl-L-glutamine and glycyl-L-tyrosine are rapidly (quantitatively) hydrolysed. The results of this study may indicate a safe and efficient parenteral use of the investigated peptides as sources of free glutamine and free tyrosine.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP39630461	Glycyl-L-tyrosine		39630-46-1	Price

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