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Bacoside-A Inhibits Inflammatory Cytokines and Chemokine in Experimental Autoimmune Encephalomyelitis

Bacoside-A Inhibits Inflammatory Cytokines and Chemokine in Experimental Autoimmune Encephalomyelitis

Krishnadas Madhu, Prakash T, Maya S

Biomed Pharmacother. 2019 Jan;109:1339-1345.

PMID: 30551384

Abstract:

Chronic inflammation of the myelin sheath is the crucial event behind the progression of multiple sclerosis (MS). Bacoside-A is one of the major constituents obtained from Bacopa monerii (L.) Wettst., and possess neuroprotective as well as anti-inflammatory actions. The current study explores the effect of Bacoside-A in acute and chronic models of Experimental Autoimmune Encephalomyelitis (EAE). The results indicate that the Bacoside-A treated mice produced a significant reduction in disease score compared to disease control in both models. The treatment with Bacoside-A downregulated the inflammatory cytokines (IL-6, IL-17a, and TNFα) and inflammatory chemokine CCL-5 in EAE mice. On the other hand, Bacoside-A treated mice showed a nonsignificant effect on promoting the expressions of NCAM, BDNF1, and FOXP3 in acute and chronic models of EAE. Histopathological analysis revealed that the Bacoside-A treated mice at a dose of 10 mg/kg exhibited a significant reduction in cellular infiltrations, cellular changes, and demyelination in cerebral tissues, but unable to protect at a higher dose in both models. In conclusion, Bacoside-A can able to inhibit the progression of EAE may be by the inhibition of inflammatory cytokines and chemokine evolved during active EAE.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP11028005	Bacoside A		11028-00-5	Price

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