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Bees' Honey Attenuation of Metanil-Yellow-Induced Hepatotoxicity in Rats

Bees' Honey Attenuation of Metanil-Yellow-Induced Hepatotoxicity in Rats

Abdulrahman L Al-Malki, Ahmed Amir Radwan Sayed

Evid Based Complement Alternat Med. 2013;2013:614580.

PMID: 23818929

Abstract:

The present study aims to investigate the protective effect of bees' honey against metanil-yellow-induced hepatotoxicity in rats. Rats were divided into 7 groups: control group; three groups treated with 50, 100, and 200 mg/kg metanil yellow, and three groups treated with metanil yellow plus 2.5 mg · kg(-1) · day(-1) bees' honey for 8 weeks. The obtained data showed that the antioxidant/anti-inflammatory activity of bees' honey reduced the oxidative stress in the liver tissue and downregulated the inflammatory markers. In addition, the elevated levels of AGE and the activated NF- κ B in the metanil-yellow-treated animals were significantly attenuated. Moreover, the levels of TNF- α and IL-1 β were significantly attenuated as a result of bees' honey administration. Furthermore, the histopathological examination of the liver showed that bees' honey reduced fatty degeneration, cytoplasmic vacuolization, and necrosis in metanil-yellow-treated rats. In conclusion, the obtained data suggest that bees' honey has hepatoprotective effect on acute liver injuries induced by metanil-yellow in vivo, and the results suggested that the effect of bees' honey against metanil yellow-induced liver damage is related to its antioxidant/anti-inflammatory properties which attenuate the activation of NF- κ B and its controlled genes like TNF- α and IL-1 β .

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP587984	Metanil Yellow		587-98-4	Price

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