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Behavioural Response to SKF 38393 and Quinpirole Following Chronic Antidepressant Treatment

Behavioural Response to SKF 38393 and Quinpirole Following Chronic Antidepressant Treatment

K Allison, S Ivanová, A J Greenshaw

Eur J Pharmacol. 1995 Apr 24;277(2-3):139-44.

PMID: 7493601

Abstract:

The effects of chronic administration of antidepressant drugs (21-22 days s.c. via osmotic mini-pumps) on the behavioural responses of male Sprague-Dawley rats to (-)-quinpirole hydrochloride (0.05 mg kg-1 s.c., 5 min) and (+/-)-SKF 38393 hydrochloride (10 mg kg-1 s.c., 5 min) were investigated. Desipramine hydrochloride (10 mg kg-1 per day), phenelzine sulphate (10 mg kg-1 per day) and clorgyline hydrochloride (1 mg kg-1 per day) attenuated the suppression of locomotor activity induced by quinpirole, a dopamine D2-like receptor agonist, while clomipramine hydrochloride (10 mg kg-1 per day) was without effect. Yawning elicited by quinpirole was absent in phenelzine- and clorgyline-treated rats, but unaffected in rats treated chronically with desipramine and clomipramine. SKF 38393, a dopamine D1-like receptor agonist, significantly increased locomotor activity and time spent grooming in control animals. There were no significant effects of antidepressants on the behavioural responses to SKF 38393.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP62717424	(±)-SKF-38393 hydrochloride		62717-42-4	Price

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