Home
Resources
Publications
Beneficial Effects of Melatonin and BQ-123 on the Rat Testis Damage Caused by Cigarette Smoke

Beneficial Effects of Melatonin and BQ-123 on the Rat Testis Damage Caused by Cigarette Smoke

Hüseyin Aslani, Hakan Kesıcı, Zafer İsmail Karaca, Birsen Özyurt, Ufuk Taş, Fatih Ekıcı, Hasan Erdoğan, Fikret Gevrek, Sevil Çayli

Turk J Med Sci. 2015;45(1):11-7.

PMID: 25790524

Abstract:

Background/aim:
Several studies have demonstrated that cigarette smoke has detrimental effects on testicular function. However, it is unknown whether melatonin or BQ-123 has beneficial effects on the rat testis damage caused by cigarette smoke. The aim of the present study was to investigate the beneficial effects of melatonin or BQ-123 on the testicular damage caused by cigarette smoke.
Materials and methods:
Twenty Wistar rats were randomly divided into 4 equal groups: control group (n = 5), cigarette smoke group (n = 5), melatonin group (n = 5), and BQ-123 group (n = 5). At the end of 4 weeks, all the rats were sacrificed for histopathological evaluation and subsequent stereological analysis. The optical fractionator counting method, the most efficient and unbiased method, was used to estimate the total number of spermatogonia and spermatocytes.
Results:
All the control testes demonstrated complete spermatogenesis. There was a significant decrease in the germ cells of rats exposed to cigarette smoke for 4 weeks. After the application of melatonin or BQ-123, the total number of spermatogonia and spermatocytes in the testes was significantly higher.
Conclusion:
Based on these findings, melatonin and BQ-123 are able to minimize the degenerative effects of cigarette smoke by increasing the germ cell count.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP136553816	BQ-123		136553-81-6	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: