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Berberine Attenuates Sodium Palmitate-Induced Lipid Accumulation, Oxidative Stress and Apoptosis in Grass carp(Ctenopharyngodon Idella)hepatocyte in Vitro

Berberine Attenuates Sodium Palmitate-Induced Lipid Accumulation, Oxidative Stress and Apoptosis in Grass carp(Ctenopharyngodon Idella)hepatocyte in Vitro

Shuo-Shuo Yang, Cheng-Bing Yu, Zhen Luo, Wen-Li Luo, Jing Zhang, Jian-Xiong Xu, Wei-Na Xu

Fish Shellfish Immunol. 2019 May;88:518-527.

PMID: 30880233

Abstract:

The objective of this work was to investigate the effect of berberine (BBR) on the Cell viability, lipid accumulation, apoptosis, cytochrome c, caspase-9 and caspase-3 in lipid accumulation-hepatocytes induced by sodium palmitate in vitro. The lipid accumulation-hepatocytes (induced by 0.5 mM sodium palmitate for 24 h) were treated with 5 μM berberine for 12 h. Then, the Cell viability, intracellular triglyceride (TG) content, lipid peroxide (LPO), malonaldehyde (MDA) content, cytochrome c, caspase-9, caspase-3 and apoptosis were detected. Sodium palmitate decreased Cell viability and increased intracellular TG content, lipid droplet accumulation, LPO and MDA concentrations, caused caspase-3 and caspase-9 activation, then led to apoptosis accompanied by cytochrome c release from mitochondria into the cytoplasm. Beberine could improve intracellular lipid droplet accumulation and oxidative stress, while reduce apoptosis induced by sodium palmitate.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP408355	Sodium palmitate		408-35-5	Price

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