Home
Resources
Publications
Beta-adrenergic Blocking Agents and Dental Vasoconstrictors

Beta-adrenergic Blocking Agents and Dental Vasoconstrictors

Elliot V Hersh, Helen Giannakopoulos

Dent Clin North Am. 2010 Oct;54(4):687-96.

PMID: 20831932

Abstract:

A clinically significant interaction between epinephrine or levonordefrin with nonselective beta-adrenergic blocking agents, although apparently rare in the dental setting, is potentially serious and can lead to significant hypertension with a concomitant reflex bradycardia. Based on the results of epinephrine infusion studies, the severity of the interaction seems dose related; small epinephrine doses cause less of a pressor response than larger doses. The interaction can be seen after intraoral submucosal injections but is generally of a smaller magnitude, at least with only 1 or 2 cartridges of lidocaine plus 1:100,000 epinephrine. However as demonstrated by 1 case report, some individuals are hypersensitive to this interaction. Inadvertent intravascular injections of local anesthetic plus vasoconstrictor and the use of high doses of vasoconstrictor are likely to result in a more pronounced response. Patients with significant cardiovascular disease may be especially vulnerable to the most serious sequelae resulting from the pressor reactions of the drug combination.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP829743-A	Levonordefrin		829-74-3	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: