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Beta-adrenoceptor Blockade and CNS-related Subjective Symptoms: A Randomized, Double-Blind, Placebo-Controlled Comparison of Metoprolol CR/ZOK, Atenolol and Propranolol LA in Healthy Subjects

Beta-adrenoceptor Blockade and CNS-related Subjective Symptoms: A Randomized, Double-Blind, Placebo-Controlled Comparison of Metoprolol CR/ZOK, Atenolol and Propranolol LA in Healthy Subjects

E Dimenäs, D Kerr, I Macdonald

J Clin Pharmacol. 1990 Feb;30(S2):S103-7.

PMID: 1968912

Abstract:

The effect of once daily treatment with atenolol (100 mg), metoprolol CR/ZOK (100 mg) and propranolol LA (160 mg) for one week on CNS-related subjective symptoms was compared with that of placebo using a randomised, double-blind cross-over design in 12 healthy volunteers. The symptoms were recorded using a previously documented self-administered questionnaire (MSE-profile), which included three dimensions: Contentment, Vitality and Sleep. Compared to placebo, all three beta-adrenoceptor antagonists reduced the exercise heart rate at 24 hours but a somewhat more pronounced effect was found with propranolol LA. No significant difference in any of the dimensions was detected between placebo and either metoprolol CR/ZOK or atenolol tablets. Following propranolol LA treatment a deterioration in the dimensions Vitality and Sleep was observed compared with both placebo and the beta 1-selective drugs. Difference in lipophilicity between the beta 1-selective agents metoprolol and atenolol has little bearing on the occurrence of the CNS-related symptoms, in comparison to the marked effects of the lipophilic and nonselective compound propranolol.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP109632088	Metoprolol Related Compound A		109632-08-8	Price

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