Home
Resources
Publications
Bile Acid Synthesis. Metabolism of 3 beta-hydroxy-5-cholenoic Acid to Chenodeoxycholic Acid

Bile Acid Synthesis. Metabolism of 3 beta-hydroxy-5-cholenoic Acid to Chenodeoxycholic Acid

N B Javitt, E Kok, F Carubbi, T Blizzard, M Gut, C Y Byon

J Biol Chem. 1986 Sep 25;261(27):12486-9.

PMID: 3745201

Abstract:

Metabolism of 3 beta-hydroxy-5-cholenoic acid to chenodeoxycholic acid has been found to occur in rabbits and humans, species that cannot 7 alpha-hydroxylate lithocholic acid. This novel pathway for chenodeoxycholic acid synthesis from 3 beta-hydroxy-5-cholenoic acid led to a reinvestigation of the pathway for chenodeoxycholic acid from 3 beta-hydroxy-5-cholenoic acid in the hamster. Simultaneous infusion of equimolar [1,2-3H]lithocholic acid and 3 beta-hydroxy-5-[14C]cholenoic acid indicated that the 14C enrichment of chenodeoxycholic acid was much greater than that of lithocholic acid. Thus, in all these species, a novel 7 alpha-hydroxylation pathway exists that prevents the deleterious biologic effects of 3 beta-hydroxy-5-cholenoic acid.

Chemicals Related in the Paper:

Catalog Number	Product Name	CAS Number	Price
AP110642427	trans-5-Hydroxyferulic acid	110642-42-7	Price
AP2905864	DL-3-Ureidoisobutyric acid	2905-86-4	Price
AP371766084	5-Isoquinolineboronic acid	371766-08-4	Price
AP379669724	But-3-enylboronic acid	379669-72-4	Price
AP619192	2-Hydroxy-nitrobenzoic acid	619-19-2	Price
AP934305	exo-5-Norbornenecarboxylic acid	934-30-5	Price
LS7931005	3-tert-Butylphenylboronic acid		Price
LS7931172	Uracil-5-boronic acid		Price
LS7931275	pyrimidine-5-boronic acid		Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: