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Biliary Excretion of the Mycotoxin Fumonisin B1 in Rats

Biliary Excretion of the Mycotoxin Fumonisin B1 in Rats

G S Shephard, P G Thiel, E W Sydenham, J F Alberts

Food Chem Toxicol. 1994 May;32(5):489-91.

PMID: 8206448

Abstract:

The biliary excretion of the mycotoxin fumonisin B1 (FB1), produced by the fungus Fusarium moniliforme Sheldon, has been measured in male Wistar rats. After ip injection of a solution of FB1 (7.5 mg/kg body weight), 67% of the applied dose was recovered in bile over a 24-hr period, 88% of this recovery being excreted in the first 4 hr after dosing. In contrast to these results, a similar dose of FB1 given by gavage resulted in only 0.2% recovery of the toxin in bile over a 24-hr period. Hence, although these results show that biliary excretion is a major route of elimination of FB1 from the circulation, only small amounts of the toxin appeared to be absorbed from the gut in rats.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1217458622	Fumonisin B1-13C34 solution		1217458-62-2	Price

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