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Binding of Helicobacter pylori to Human Gastric Mucins Correlates with Binding of TFF1

Binding of Helicobacter pylori to Human Gastric Mucins Correlates with Binding of TFF1

Ciara Dunne, Julie Naughton, Gina Duggan, Catherine Loughrey, Michelle Kilcoyne, Lokesh Joshi, Stephen Carrington, Helen Earley, Steffen Backert, Catherine Robbe Masselot, Felicity E B May, Marguerite Clyne

Microorganisms. 2018 May 18;6(2):44.

PMID: 29783620

Abstract:

Helicobacter pylori binds to the gastric mucin, MUC5AC, and to trefoil factor, TFF1, which has been shown to interact with gastric mucin. We examined the interactions of TFF1 and H. pylori with purified gastrointestinal mucins from different animal species and from humans printed on a microarray platform to investigate whether TFF1 may play a role in locating H. pylori in gastric mucus. TFF1 bound almost exclusively to human gastric mucins and did not interact with human colonic mucins. There was a strong correlation between binding of TFF1 and H. pylori to human gastric mucins, and between binding of both TFF1 and H. pylori to gastric mucins with that of Griffonia simplicifolia lectin-II, which is specific for terminal non-reducing α- or β-linked N-acetyl-d-glucosamine. These results suggest that TFF1 may help to locate H. pylori in a discrete layer of gastric mucus and hence restrain their interactions with epithelial cells.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42414470	TFF1 human			Price

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