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Binucleine 2, an Isoform-Specific Inhibitor of Drosophila Aurora B Kinase, Provides Insights Into the Mechanism of Cytokinesis

Yegor Smurnyy, Angela V Toms, Gilles R Hickson, Michael J Eck, Ulrike S Eggert

ACS Chem Biol. 2010 Nov 19;5(11):1015-20.

PMID: 20804174

Abstract:

Aurora kinases are key regulators of cell division and important targets for cancer therapy. We report that Binucleine 2 is a highly isoform-specific inhibitor of Drosophila Aurora B kinase, and we identify a single residue within the kinase active site that confers specificity for Aurora B. Using Binucleine 2, we show that Aurora B kinase activity is not required during contractile ring ingression, providing insight into the mechanism of cytokinesis.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP220088426 Binucleine 2 Binucleine 2 220088-42-6 Price
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