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Bioactive Sulfur-Containing Sulochrin Dimers and Other Metabolites From an Alternaria Sp. Isolate From a Hawaiian Soil Sample

Bioactive Sulfur-Containing Sulochrin Dimers and Other Metabolites From an Alternaria Sp. Isolate From a Hawaiian Soil Sample

Shengxin Cai, Jarrod B King, Lin Du, Douglas R Powell, Robert H Cichewicz

J Nat Prod. 2014 Oct 24;77(10):2280-7.

PMID: 25265160

Abstract:

Polluxochrin (1) and dioschrin (2), two new dimers of sulochrin linked by thioether bonds, were purified from an Alternaria sp. isolate obtained from a Hawaiian soil sample. The structures of the two metabolites were established by NMR, mass spectrometry data, and X-ray analysis. Metabolite 1 was determined to be susceptible to intramolecular cyclization under aqueous conditions, resulting in the generation of 2 as well as another dimeric compound, castochrin (3). An additional nine new metabolites were also obtained, including four new pyrenochaetic acid derivatives (8-11), one new asterric acid analogue (13), and four new secalonic acid analogues (14-17). Bioassay analysis of these compounds revealed 1-3 displayed antimicrobial and weak cytotoxic activities.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP519573	Sulochrin		519-57-3	Price

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