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Bioactivity-guided Separation of the Active Compounds in Acacia Pennata Responsible for the Prevention of Alzheimer's Disease

Bioactivity-guided Separation of the Active Compounds in Acacia Pennata Responsible for the Prevention of Alzheimer's Disease

Pattamapan Lomarat, Sirirat Chancharunee, Natthinee Anantachoke, Worawan Kitphati, Kittisak Sripha, Nuntavan Bunyapraphatsara

Nat Prod Commun. 2015 Aug;10(8):1431-4.

PMID: 26434135

Abstract:

The objective of this study was to evaluate the health benefits of plants used in Thai food, specifically Acacia pennata Willd., in Alzheimer's prevention. A. pennata twigs strongly inhibited β-amyloid aggregation. Bioactivity-guided separation of the active fractions yielded six known compounds, tetracosane (1), 1-(heptyloxy)-octadecane (2), methyl tridecanoate (3), arborinone (4), confertamide A (5) and 4-hydroxy-1-methyl-pyrrolidin-2-carboxylic acid (6). The structures were determined by spectroscopic analysis. Biological testing revealed that tetracosane (1) was the most potent inhibitor of β-amyloid aggregation, followed by 1-(heptyloxy)-octadecane (2) with IC50 values of 0.4 and 12.3 μM. Methyl tridecanoate (3), arborinone (4) and 4-hydroxy-1-methyl-pyrrolidin-2-carboxylic acid (6) moderately inhibited β-amyloid aggregation. In addition, tetracosane (1) and methyl tridecanoate (3) weakly inhibited acetylcholinesterase (AChE). These results suggested that the effect of A. pennata on Alzheimer's disease was likely due to the inhibition of β-amyloid aggregation. Thus A. pennata may be beneficial for Alzheimer's prevention.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1731880	Methyl tridecanoate		1731-88-0	Price

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