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Biocatalyst Mediated Regio- And Stereo-Selective Hydroxylation and Epoxidation of (Z)-α-santalol

Pankaj P Daramwar, Prabhakar Lal Srivastava, Swati P Kolet, Hirekodathakallu V Thulasiram

Org Biomol Chem. 2014 Feb 21;12(7):1048-51.

PMID: 24407157

Abstract:

Biocatalyst mediated regio- and stereo-selective hydroxylation and epoxidation on (Z)-α-santalol were achieved for the first time, using a fungal strain Mucor piriformis. Four novel metabolites were characterized as 10,11-cis-β-epoxy-α-santalol, 5α-hydroxy-(Z)-α-santalol, 10,11-dihydroxy-α-santalol and 5α-hydroxy-10,11-cis-β-epoxy-α-santalol. Using Amano PS lipase from Burkholderia cepacia, α- and β-isomers of 10,11-cis-epoxy-α-santalol were resolved efficiently.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
IAR42416025 Amano Lipase PS, from Burkholderia cepacia Amano Lipase PS, from Burkholderia cepacia Price
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