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Biocide Potentiation Using Cinnamic Phytochemicals and Derivatives

Biocide Potentiation Using Cinnamic Phytochemicals and Derivatives

Joana F Malheiro, Jean-Yves Maillard, Fernanda Borges, Manuel Simões

Molecules. 2019 Oct 30;24(21):3918.

PMID: 31671687

Abstract:

Surface disinfection is of utmost importance in the prevention of bacterial infections. This study aims to assess the ability of ten phytochemicals and related derivatives as potentiators of two commonly used biocides-cetyltrimethylammonium bromide (CTAB) and lactic acid (LA). LA in combination with cinnamic, hydrocinnamic, α-methylcinnamic, and α-fluorocinnamic acids had a factional inhibitory concentration index (FICI) ≤ 1 for Escherichia coli and Staphylococcus aureus. Several phytochemicals/derivatives in combination with biocides improved the biocidal efficacy against early sessile bacteria. The most effective combination was LA with allyl cinnamate (2.98 ± 0.76 log CFU.cm-2 reduction) against E. coli. The combination with CTAB was successful for most phytochemicals/derivatives with a maximum bactericidal efficacy against sessile E. coli when combined with allyl cinnamate (2.20 ± 0.07 log CFU.cm-2 reduction) and for S. aureus when combined with α-methylcinnamic acid (1.68 ± 0.30 log CFU.cm-2 reduction). This study highlights the potential of phytochemicals and their derivatives to be used in biocide formulations.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1866315	Allyl cinnamate		1866-31-5	Price

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