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Biocompatible Disulphide Cross-Linked Sodium Alginate Derivative Nanoparticles for Oral Colon-Targeted Drug Delivery

Biocompatible Disulphide Cross-Linked Sodium Alginate Derivative Nanoparticles for Oral Colon-Targeted Drug Delivery

Asila Dinie Ayub, Hock Ing Chiu, Siti Nur Aishah Mat Yusuf, Erazuliana Abd Kadir, Siti Hawa Ngalim, Vuanghao Lim

Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):353-369.

PMID: 30691309

Abstract:

The application of layer-by-layer (LbL) approach on nanoparticle surface coating improves the colon-specific drug delivery of insoluble drugs. Here, we aimed to formulate a self-assembled cysteamine-based disulphide cross-linked sodium alginate with LbL self-assembly to improve the delivery of paclitaxel (PCX) to colonic cancer cells. Cysteamine was conjugated to the backbone of oxidized SA to form a core of self-assembled disulphide cross-linked nanospheres. P3DL was selected for PCX loading and fabricated LbL with poly(allylamine hydrochloride) (PAH) and poly(4-styrenesulfonic acid-co-maleic acid) sodium salt (PSSCMA) resulting from characterization and drug release studies. P3DL-fabricated PCX-loaded nanospheres (P3DL/PAH/PSSCMA) exhibited an encapsulation efficiency of 77.1% with cumulative drug release of 45.1%. Dynamic light scattering analysis was reported at 173.6 ± 2.5 nm with polydispersity index of 0.394 ± 0.105 (zeta potential= -58.5 mV). P3DL/PAH/PSSCMA demonstrated a pH-dependent swelling transition; from pH 1 to 7 (102.2% increase). The size increased by 33.0% in reduction response study after incubating with 10 mM glutathione (day 7). HT-29 cells showed high viabilities (86.7%) after treatment with the fabricated nanospheres at 0.8 µg/mL. Cellular internalization was successful with more than 70.0% nanospheres detected in HT-29 cells. Therefore, this fabricated nanospheres may be considered as potential nanocarriers for colon cancer-targeted chemotherapeutic drug delivery.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP3105553	Maleic acid sodium salt		3105-55-3	Price
AP9080799	Poly(styrenesulfonic acid sodium salt)		9080-79-9	Price

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