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Biodegradable Amphiphilic Block-Graft Copolymers Based on Methoxy Poly(ethylene Glycol)-B-(Polycarbonates-G-Polycarbonates) for Controlled Release of Doxorubicin

Biodegradable Amphiphilic Block-Graft Copolymers Based on Methoxy Poly(ethylene Glycol)-B-(Polycarbonates-G-Polycarbonates) for Controlled Release of Doxorubicin

Tao Jiang, Youmei Li, Yin Lv, Yinjia Cheng, Feng He, Renxi Zhuo

J Mater Sci Mater Med. 2014 Jan;25(1):131-9.

PMID: 24062230

Abstract:

In this paper, novel biodegradable amphiphilic block-graft copolymers based on methoxy poly(ethylene glycol)-b-(polycarbonates-g-polycarbonates) (mPEG-b-(PATMC-g-PATMC)) were synthesized successfully for controlled release of doxorubicin (DOX). Backbone block copolymer, methoxy poly(ethylene glycol)-b-poly(5-allyloxy-1,3-dioxan-2-one) (mPEG-b-PATMC) was synthesized in bulk catalyzed by immobilized porcine pancreas lipase (IPPL). Then, mPEG-b-PATMC-O, the allyl epoxidation product of mPEG-b-PATMC, was further grafted by PATMC itself also using IPPL as the catalyst. The copolymers were characterized by (1)N HMR and gel permeation chromatography results showed narrow molecular weight distributions. Stable micelle solutions could be prepared by dialysis method, while a monomodal and narrow size distribution could be obtained. Transmission electron microscopy (TEM) observation showed the micelles dispersed in spherical shape with nano-size before and after DOX loading. Compared with the block copolymers, the grafted structure could enhance the interaction of polymer chains with drug molecules and improve the drug-loading capacity and entrapment efficiency. Furthermore, the amphiphilic block-graft copolymers mPEG-b-(PATMC-g-PATMC) had low cytotoxicity and more sustained drug release behavior.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS74313	Poly(L-lactide-co-5-methyl-5-allyloxycarbonyl-1,3-dioxan- 2-one)			Price

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