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Biodegradable Ethylene-Bis(propyl)disulfide-Based Periodic Mesoporous Organosilica Nanorods and Nanospheres for Efficient In-Vitro Drug Delivery

Jonas Croissant, Xavier Cattoën, Michel Wong Chi Man, Audrey Gallud, Laurence Raehm, Philippe Trens, Marie Maynadier, Jean-Olivier Durand

Adv Mater. 2014 Sep 17;26(35):6174-80.

PMID: 25042639

Abstract:

Periodic mesoporous organosilica nanorods and nanospheres are synthesized from 1,4-bis(triethoxysilyl)ethylene and bis(3-ethoxysilylpropyl)disulfide. The nanosystems present the long-range order of the hexagonal nanostructure. They are degraded in simulated physiological conditions. The loading and release of doxorubicin with these nanosystems are both pH dependent. These nanoparticles are endocytosed by breast cancer cells and are very efficient for doxorubicin delivery in these cells.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP112141283 Bis(16-Hydroxyhexadecyl) disulfide Bis(16-Hydroxyhexadecyl) disulfide 112141-28-3 Price
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