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Biofunctional Soyasaponin Bb in Peanut (Arachis Hypogaea L.) Sprouts Enhances Bone Morphogenetic protein-2-dependent Osteogenic Differentiation via Activation of Runt-Related Transcription Factor 2 in C2C12 Cells

Biofunctional Soyasaponin Bb in Peanut (Arachis Hypogaea L.) Sprouts Enhances Bone Morphogenetic protein-2-dependent Osteogenic Differentiation via Activation of Runt-Related Transcription Factor 2 in C2C12 Cells

Shin-Hye Kim, Heung Joo Yuk, Hyung Won Ryu, Sei-Ryang Oh, Duk Young Song, Kwang-Sik Lee, Kie-In Park, Sik-Won Choi, Woo Duck Seo

Phytother Res. 2019 May;33(5):1490-1500.

PMID: 30883927

Abstract:

Improvement of bone formation is necessary for successful treatment of the bone defects associated with osteoporosis. In this study, we sought to elucidate the osteogenic activity of peanut sprouts and their bioactive components. We found that peanut sprout water extract (PSWE) enhanced bone morphogenetic protein-2-mediated osteoblast differentiation in a dose-dependent manner by stimulating expression of runt-related transcription factor 2 (Runx2) via activation of AKT/MAP kinases. We identified a major component of PSWE, soyasaponin Bb, as the bioactive compound responsible for improvement of anabolic activity. Soyasaponin Bb from PSWE enhanced expression of the osteogenic transcription factor Runx2 and alkaline phosphatase. The soyasaponin Bb content depended on sprouting time of peanut, and the anabolic action of PSWE was dependent on soyasaponin Bb content. Thus, PSWE and soyasaponin Bb have the potential to protect against bone disorders, including osteoporosis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP51330279	Soyasaponin Bb		51330-27-9	Price

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