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Biogenic Aldehyde Determination by Reactive Paper Spray Ionization Mass Spectrometry

Biogenic Aldehyde Determination by Reactive Paper Spray Ionization Mass Spectrometry

Soumabha Bag, P I Hendricks, J C Reynolds, R G Cooks

Anal Chim Acta. 2015 Feb 20;860:37-42.

PMID: 25682245

Abstract:

Ionization of aliphatic and aromatic aldehydes is improved by performing simultaneous chemical derivatization using 4-aminophenol to produce charged iminium ions during paper spray ionization. Accelerated reactions occur in the microdroplets generated during the paper spray ionization event for the tested aldehydes (formaldehyde, n-pentanaldehyde, n-nonanaldehyde, n-decanaldehyde, n-dodecanaldehyde, benzaldehyde, m-anisaldehyde, and p-hydroxybenzaldehyde). Tandem mass spectrometric analysis of the iminium ions using collision-induced dissociation demonstrated that straight chain aldehydes give a characteristic fragment at m/z 122 (shown to correspond to protonated 4-(methyleneamino)phenol), while the aromatic aldehyde iminium ions fragment to give a characteristic product ion at m/z 120. These features allow straightforward identification of linear and aromatic aldehydes. Quantitative analysis of n-nonaldehyde using a benchtop mass spectrometer demonstrated a linear response over 3 orders of magnitude from 2.5 ng to 5 μg of aldehyde loaded on the filter paper emitter. The limit of detection was determined to be 2.2 ng for this aldehyde. The method had a precision of 22%, relative standard deviation. The experiment was also implemented using a portable ion trap mass spectrometer.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP591311	m-Anisaldehyde		591-31-1	Price

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