Home
Resources
Publications
Biology and Signal Transduction Pathways of the Lymphotoxin-αβ/LTβR System

Biology and Signal Transduction Pathways of the Lymphotoxin-αβ/LTβR System

Caroline Remouchamps, Layla Boutaffala, Corinne Ganeff, Emmanuel Dejardin

Cytokine Growth Factor Rev. Oct-Dec 2011;22(5-6):301-10.

PMID: 22152226

Abstract:

This review focuses on the biological functions and signalling pathways activated by Lymphotoxin α (LTα)/Lymphotoxin β (LTβ) and their receptor LTβR. Genetic mouse models shed light on crucial roles for LT/LTβR to build and to maintain the architecture of lymphoid organs and to ensure an adapted immune response against invading pathogens. However, chronic inflammation, autoimmunity, cell death or cancer development are disorders that occur when the LT/LTβR system is twisted. Biological inhibitors, such as antagonist antibodies or decoy receptors, have been developed and used in clinical trials for diseases associated to the LT/LTβR system. Recent progress in the understanding of cellular trafficking and NF-κB signalling pathways downstream of LTα/LTβ may bring new opportunities to develop therapeutics that target the pathological functions of these cytokines.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413760	Lymphotoxin-α1/β2 human			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: