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Biosynthesis of [1-15N] L-tryptophan From 15N Labeled Anthranilic Acid by Fermentation of Candida Utilis Mutant

Zhanfeng Liu, Qipeng Yuan, Wenchuan Wang

Amino Acids. 2009 Jan;36(1):71-3.

PMID: 18235989

Abstract:

A new method for synthesizing the labeled L-tryptophan is described in this work. L-tryptophan, labeled with 98% (15)N at position 1 was synthesized from the labeled anthranilic acid using Candida utilis mutants. The conversion ratio of (15)N of 50% was achieved. The labeled anthranilic acid was synthesized by [(15)N] phthalimide that was prepared by 99.34% [(15)N] urea and phthalic anhydride in ortho-xylene medium at 140 degrees C and under atmospheric pressure.

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AP202407305 L-Valine-13C5,15N L-Valine-13C5,15N 202407-30-5 Price
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