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Biosynthesis of the Pyoverdine Siderophore of Pseudomonas Aeruginosa Involves Precursors With a Myristic or a Myristoleic Acid Chain

Biosynthesis of the Pyoverdine Siderophore of Pseudomonas Aeruginosa Involves Precursors With a Myristic or a Myristoleic Acid Chain

Mélissa Hannauer, Mathias Schäfer, Françoise Hoegy, Patrick Gizzi, Patrick Wehrung, Gaëtan L A Mislin, Herbert Budzikiewicz, Isabelle J Schalk

FEBS Lett. 2012 Jan 2;586(1):96-101.

PMID: 22172280

Abstract:

Pyoverdine I (PVDI) is the major siderophore produced by Pseudomonas aeruginosa to import iron. Biosynthesis of this chelator involves non-ribosomal peptide synthetases and other enzymes. PvdQ is a periplasmic enzyme from the NTN hydrolase family and is involved in the final steps of PVDI biosynthesis. A pvdQ mutant produces two non-fluorescent PVDI precursors with a higher molecular mass than PVDI. In the present study, we describe the use of mass spectrometry to determine the structure of these PVDI precursors and show that they both contain a unformed chromophore like ferribactin, and either a myristic or myristoleic chain that must be removed before PVDI is secreted into the extracellular medium.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP544649	Myristoleic acid		544-64-9	Price

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