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Biosynthetic Pathway for a New Series of Gangliosides, GT1a Alpha and GQ1b Alpha

Biosynthetic Pathway for a New Series of Gangliosides, GT1a Alpha and GQ1b Alpha

F Irie, K I Hidari, T Tai, Y T Li, Y Seyama, Y Hirabayashi

FEBS Lett. 1994 Sep 5;351(2):291-4.

PMID: 8082783

Abstract:

A new class of gangliosides, GT1a alpha and GQ1b alpha, were initially identified as cholinergic neuron-specific antigens in bovine brain. These gangliosides have in common alpha 2-6 NeuAc linked to the GalNAc residue in the gangliotetraose core structure. In this study, we have determined the biosynthetic pathways of GT1a alpha and GQ1b alpha using rat liver Golgi fraction. The results showed that GT1a alpha and GQ1b alpha were synthesized from GD1a and GT1b, respectively, by the action of a GalNAc alpha 2-6 sialyltransferase. It was also demonstrated that these two gangliosides were found to exist as extremely minor components in rat liver.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP59247131	Trisialoganglioside-GT1b from bovine brain		59247-13-1	Price

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