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Biosynthetic Studies on a Myxobacterial Antibiotic, Cystothiazole A: Biosynthetic Precursors of the Carbon Skeleton

Biosynthetic Studies on a Myxobacterial Antibiotic, Cystothiazole A: Biosynthetic Precursors of the Carbon Skeleton

Yoshihiro Suzuki, Youji Sakagami, Makoto Ojika

J Antibiot (Tokyo). 2003 Apr;56(4):372-8.

PMID: 12817811

Abstract:

Biosynthetic studies on cystothiazole A (1), a beta-methoxyacrylate-type antifungal compound from a myxobacterium, were performed by feeding the producing organism, Cystobacter fuscus, with stable-isotope-labeled compounds including [2-(13)C]acetate, [1,2-(13)C2]acetate, [1-(13)C]propionate, L-[1-(13)C]serine, L-[methyl-(13)C]methionine, and DL-valine-d8. The polyketide moiety of 1 was found to be derived from acetate and propionate, the bithiazole moiety from L-serine, the O-methyl groups from the S-methyl group of L-methionine, and the isopropyl moiety from L-valine, which should be the metabolic precursor of isobutyryl-CoA.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP203784638	DL-Valine-d8		203784-63-8	Price

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