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Biotransformation of Huperzine B by a Fungal Endophyte of Huperzia Serrata

Biotransformation of Huperzine B by a Fungal Endophyte of Huperzia Serrata

Zha-Jun Zhan, Ting Tian, Yi-Lian Xu, Hang-Fei Yu, Cai-Xue Zhang, Zhi-Dong Zhang, Qi-Yong Tang, Wei-Guang Shan, You-Min Ying

Chem Biodivers. 2019 Aug;16(8):e1900299.

PMID: 31287220

Abstract:

The biotransformation of huperzine B (hupB), one of the characteristic bioactive constituents of the medicinal plant Huperzia serrata, by a fungal endophyte of the host plant was studied. One new compound, 8α,15α-epoxyhuperzine B (1), along with two known oxygenated hupB analogs, 16-hydroxyhuperzine B (2) and carinatumin B (3), was isolated and identified. The structures of all the isolates were deduced by spectroscopic methods including NMR, MS, IR, and UV spectra. The known compounds 2 and 3 were obtained from a microbial source for the first time. To the best of our knowledge, it is the first report on the microbial transformation of hupB and would facilitate further structural modification of hupB by chemo-enzymatic method. In the LPS-induced neuro-inflammation injury assay, 8α,15α-epoxyhuperzine B (1) exhibited moderate neuroprotective activity by increasing the viability of U251 cell lines with an EC50 of 40.1 nm.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP103548829	Huperzine B		103548-82-9	Price

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