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Biotransformation of Rosamicin Antibiotic Into 10,11-dihydrorosamicin With Enhanced in Vitro Antibacterial Activity Against MRSA

Biotransformation of Rosamicin Antibiotic Into 10,11-dihydrorosamicin With Enhanced in Vitro Antibacterial Activity Against MRSA

Nguyen Lan Huong, Nguyen Huu Hoang, Anil Shrestha, Jae Kyung Sohng, Yeo Joon Yoon, Je Won Park

J Microbiol Biotechnol. 2014 Jan;24(1):44-7.

PMID: 24064918

Abstract:

A biotransformation approach using microbes as biocatalysts can be an efficient tool for the targeted modification of existing antibiotic chemical scaffolds to create previously uncharacterized therapeutic agents. By employing a recombinant Streptomyces venezuelae strain as a microbial catalyst, a reduced macrolide, 10,11-dihydrorosamicin, was created from rosamicin macrolide. Its chemical structure was spectroscopically elucidated, and the new rosamicin analog showed 2-4-fold higher antibacterial activity against two strains of methicillin-resistant Staphylococcus aureus compared with its parent rosamicin. This kind of biocatalytic approach is able to expand existing antibiotic entities and can also provide more diverse therapeutic resources.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP35834265	Rosamicin		35834-26-5	Price

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