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Bipolar and Related Disorders Induced by Sodium 4-Phenylbutyrate in a Male Adolescent With Bile Salt Export Pump Deficiency Disease

Bipolar and Related Disorders Induced by Sodium 4-Phenylbutyrate in a Male Adolescent With Bile Salt Export Pump Deficiency Disease

Giovanni Vitale, Giulia Simonetti, Martina Pirillo, Gianfranco Taruschio, Pietro Andreone

Psychiatry Investig. 2016 Sep;13(5):580-582.

PMID: 27757140

Abstract:

Bile Salt Export Pump (BSEP) Deficiency disease, including Progressive Familial Intrahepatic Cholestasis type 2 (PFIC2), is a rare disease, usually leading within the first ten years to portal hypertension, liver failure, hepatocellular carcinoma. Often liver transplantation is needed. Sodium 4-phenylbutyrate (4-PB) seems to be a potential therapeutic compound for PFIC2. Psychiatric side effects in the adolescent population are little known and little studied since the drug used to treat children and infants. So we described a case of Caucasian boy, suffering from a late onset PFIC2, listed for a liver transplant when he was sixteen and treated with 4-FB (200 mg per kilogram of body weight per day). The drug was discontinued for the onset of bipolar and related disorders. This case illustrates possible psychiatric side effects of the drug.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP2051958	Phenylbutyrate Related Compound A		2051-95-8	Price

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