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Black Soybean Extract Protects Against TMT-induced Cognitive Defects in Mice

Black Soybean Extract Protects Against TMT-induced Cognitive Defects in Mice

Ji Hee Jeong, Yu Na Jo, Hyeon Ju Kim, Dong Eun Jin, Dae-Ok Kim, Ho Jin Heo

J Med Food. 2014 Jan;17(1):83-91.

PMID: 24456358

Abstract:

To find a neuroactive compound with a potent inhibitory effect on acetylcholinesterase (AChE) and in vivo anti-amnesic activity from natural resources, we evaluated anthocyanins and nonanthocyanins from black soybean extract. Nonanthocyanins from black soybean extract were the most potent and dose-dependent AChE inhibitors. Intracellular reactive oxygen species accumulation resulting from H₂O₂ treatment was significantly decreased compared with cells treated with H₂O₂ only. Nonanthocyanins were also neuroprotective against H₂O₂ treated neurotoxicity by 3-[4,5-dimethythiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) and lactate dehydrogenase (LDH) assay. Finally, nonanthocyanins from black soybean in the preadministration group attenuated trimethyltin (TMT)-induced memory injury in both in vivo tests. AChE, prepared from mice brain tissues, was inhibited by nonanthocyanins from black soybean in a dose-dependent manner. Malondialdehyde generation in the brain homogenates of mice treated with nonanthocyanins from black soybean was decreased. We concluded that nonanthocyanins from black soybean had an efficacious in vitro AChE inhibitory activity, and protected against H₂O₂-induced neurotoxicity. In addition, our findings suggest that nonanthocyanins from black soybean may improve the TMT-induced learning and memory deficit because of AChE inhibition of mice brain tissue. Consequently, these results demonstrate that the nonanthocyanins from black soybean could possess a wide range of beneficial activities for neurodegenerative disorders.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1066440	Trimethyltin bromide		1066-44-0	Price

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