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BLT-1, a Specific Inhibitor of the HDL Receptor SR-BI, Induces a Copper-Dependent Phenotype During Zebrafish Development

BLT-1, a Specific Inhibitor of the HDL Receptor SR-BI, Induces a Copper-Dependent Phenotype During Zebrafish Development

Demetrio Raldúa, Patrick J Babin

Toxicol Lett. 2007 Dec 10;175(1-3):1-7.

PMID: 17890024

Abstract:

Block lipid transport-1 (BLT-1) is a small chemical widely used to inhibit the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by scavenger receptor B, type 1 (SR-BI). This study demonstrated that BLT-1 induced in zebrafish (Danio rerio) embryos a copper-dependent phenotype with a twisted notochord, brain ventricle enlargement, and absence of melanisation, phenocopying neocuproine-treated, or calamity mutants. This finding supports an unexpected link between copper availability and SR-BI activity. The copper-chelating activity of BLT-1, revealed by its dramatic effect during embryo development, should be considered in any evaluation of the pharmacological effect of this thiosemicarbazone derivative on SR-BI activity and the potential therapeutic value of this molecule.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP321673307	BLT-1		321673-30-7	Price

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