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BMH-21 Inhibits Viability and Induces Apoptosis by p53-dependent Nucleolar Stress Responses in SKOV3 Ovarian Cancer Cells

BMH-21 Inhibits Viability and Induces Apoptosis by p53-dependent Nucleolar Stress Responses in SKOV3 Ovarian Cancer Cells

Xinxu Fu, Lu Xu, Ling Qi, Hongyan Tian, Dan Yi, Yang Yu, Shibing Liu, Songyan Li, Ye Xu, Chunyan Wang

Oncol Rep. 2017 Aug;38(2):859-865.

PMID: 28656213

Abstract:

The nucleolus is a stress sensor associated with cell cycle progression and apoptosis. Studies have shown that nucleolar stress is positively correlated with apoptosis in breast, prostate and lung cancer cells. However, the role and function of nucleolar stress in ovarian cancer has not been reported. In this study, we found that the nucleolar stress inducer BMH-21 inhibited viability of SKOV3 ovarian cancer cells in a dose-dependent manner. Furthermore, BMH-21 induced the expression of nucleolar stress marker proteins (nucleolin, nucleophosmin and fibrillarin) and promoted the nuclear export of these proteins. BMH-21 also decreased MDM2 proto-oncogene expression and increased protein levels of the tumor suppressor p53 and p53 phosphorylated at serine 15 (p‑p53‑Ser15), which contributed to increased expression of the downstream apoptosis-related protein BCL2 associated X (BAX) and activation of caspase-3. Taken together, these data provide the first reported evidence that induction of p53-dependent nucleolar stress by BMH-21 induces apoptosis in ovarian cancer. Our data suggest that nucleolar stress might be a pathway suitable for targeting in ovarian cancer.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP896705161	BMH-21		896705-16-1	Price

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