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BMP Signalling: Agony and Antagony in the Family

BMP Signalling: Agony and Antagony in the Family

Derek P Brazil, Rachel H Church, Satnam Surae, Catherine Godson, Finian Martin

Trends Cell Biol. 2015 May;25(5):249-64.

PMID: 25592806

Abstract:

Bone morphogenetic proteins (BMPs) are secreted extracellular matrix (ECM)-associated proteins that regulate a wide range of developmental processes, including limb and kidney formation. A critical element of BMP regulation is the presence of secreted antagonists that bind and inhibit BMP binding to their cognate Ser/Thr kinase receptors at the plasma membrane. Antagonists such as Noggin, Chordin, Gremlin (Grem1), and twisted gastrulation-1 (Twsg1) have been shown to inhibit BMP action in a range of different cell types and developmental stage-specific contexts. Here we review new developments in the field of BMP and BMP antagonist biology during mammalian development and suggest strategies for targeting these proteins in human disease.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413735	Noggin human			Price

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