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Boric Acid and Boronic Acids Inhibition of Pigeonpea Urease

K Ravi Charan Reddy, Arvind M Kayastha

J Enzyme Inhib Med Chem. 2006 Aug;21(4):467-70.

PMID: 17059182

Abstract:

Urease from the seeds of pigeonpea was competitively inhibited by boric acid, butylboronic acid, phenylboronic acid, and 4-bromophenylboronic acid; 4-bromophenylboronic acid being the strongest inhibitor, followed by boric acid > butylboronic acid > phenylboronic acid, respectively. Urease inhibition by boric acid is maximal at acidic pH (5.0) and minimal at alkaline pH (10.0), i.e., the trigonal planar B(OH)3 form is a more effective inhibitor than the tetrahedral B(OH)4 -anionic form. Similarly, the anionic form of phenylboronic acid was least inhibiting in nature.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP4426475 Butylboronic acid Butylboronic acid 4426-47-5 Price
AP5467743 4-Bromophenylboronic acid 4-Bromophenylboronic acid 5467-74-3 Price
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