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Boronic acid functionalized g-C 3 N 4 nanosheets for ultrasensitive and selective sensing of glycoprotein in the physiological environment

Boronic acid functionalized g-C 3 N 4 nanosheets for ultrasensitive and selective sensing of glycoprotein in the physiological environment

Yiting Wang, Xin Hai, Shuang E, Mingli Chen, Ting Yang, Jianhua Wang

Nanoscale. 2018 Mar 8;10(10):4913-4920.

PMID: 29480294

Abstract:

As important biomarkers, glycoprotein sensing is frequently facilitated by boronic acid binding with its cis-diols. However, boronic acid based sensors suffer from drawbacks of alkali restriction and/or sensitivity limitation. Herein, we report boronic acid decorated g-C3N4 nanosheets (B-g-CN) with a Wulff-type boronic acid feature, which selectively bind glycoprotein under physiological conditions. Meanwhile, the binding causes significant enhancement of the B-g-CN nanosheet fluorescence, providing the basis for glycoprotein sensing. With IgG as a model, a detection limit (LOD) of 2.2 nM (3σ/s, n = 11) was obtained within a linear range of 6.7-67 nM. The LOD was further improved to 52 pM subject to enrichment of the nanosheets, which well enables IgG assay in human urine samples. Moreover, it was successful in imaging endogenous and exogenous glycoproteins in living cells.

Chemicals Related in the Paper:

Catalog Number	Product Name	CAS Number	Price
AP475102126	(N-Boc-5-chloro-2-indolyl)boronic acid	475102-12-6	Price
LS7931253	5-cyano-3-pyridinyl boronic acid		Price
LS793652	3-methoxy-2-hydroxyphenyl boronic acid		Price
LS793655	2-hydroxy-3-methylphenyl boronic acid		Price

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