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Boronic Acid-Functionalized Two-Dimensional MoS 2 at Biointerfaces

Boronic Acid-Functionalized Two-Dimensional MoS 2 at Biointerfaces

Shabnam Sattari, Siamak Beyranvand, Khadijeh Soleimani, Kiarash Rossoli, Pouya Salahi, Ievgen S Donskyi, Azim Shams, Wolfgang E S Unger, Abdolah Yari, Ghasem Farjanikish, Hassan Nayebzadeh, Mohsen Adeli

Langmuir. 2020 Jun 23;36(24):6706-6715.

PMID: 32441938

Abstract:

While noncovalent interactions at two-dimensional nanobiointerfaces are extensively investigated, less knowledge about covalent interactions at this interface is available. In this work, boronic acid-functionalized 2D MoS2 was synthesized and its covalent multivalent interactions with bacteria and nematodes were investigated. Polymerization of glycidol by freshly exfoliated MoS2 and condensation of 2,5-thiophenediylbisboronic acid on the produced platform resulted in boronic acid-functionalized 2D MoS2. The destructive interactions between 2D MoS2 and bacteria as well as nematodes were significantly amplified by boronic acid functional groups. Because of the high antibacterial and antinematodal activities of boronic acid-functionalized 2D MoS2, its therapeutic efficacy for diabetic wound healing was investigated. The infected diabetic wounds were completely healed 10 days after treatment with boronic acid-functionalized 2D MoS2, and a normal structure for recovered tissues including different layers of skin, collagen, and blood vessels was detected.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP26076460	2,5-Thiophenediylbisboronic acid		26076-46-0	Price

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