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Borrelidins F-I, Cytotoxic and Cell Migration Inhibiting Agents From Mangrove-Derived Streptomyces Rochei SCSIO ZJ89

Borrelidins F-I, Cytotoxic and Cell Migration Inhibiting Agents From Mangrove-Derived Streptomyces Rochei SCSIO ZJ89

Jianbin Sun, Junli Shao, Changli Sun, Yongxiang Song, Qinglian Li, Laichun Lu, Yunfeng Hu, Chun Gui, Hua Zhang, Jianhua Ju

Bioorg Med Chem. 2018 May 1;26(8):1488-1494.

PMID: 29452840

Abstract:

Borrelidin A (1) is produced by several species of Streptomyces and within its bioactive scaffold, the vinylic nitrile moiety is essential for activity. We report herein newly discovered members of the borrelidin family, borrelidin F (2), borrelidin G (3), borrelidin H (4) and borrelidin I (5); all were isolated from Streptomyces rochei SCSIO ZJ89 originating from a mangrove-derived sediment sample. These structurally diverse metabolites enabled a number of new structure-activity relationships (SARs) to be identified, especially with respect to the different configurations at the C11-OH and C12-C15 double bonds for which the absolute configurations were determined using spectroscopic methods. Importantly, borrelidin H (4) was found to have a therapeutic window superior to that of borrelidin A (1) in vitro and could inhibit migration of cancer cells.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP7184603	Borrelidin		7184-60-3	Price

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